The regulatory systems categorized into three types, neural, humoral and behavioral　mechanisms play an important role in maintenance of the homeostasis of the body. These control systems response and compensate by the second, by the minute, by the hour, by the day or by the year to the internal or external stress. Thus, we can preserve and promote our health. The worse lifestyle could induce a breakdown in these regulatory systems, and cause lifestyle-related diseases such as diabetes mellitus, hypertension, atherosclerosis, ischemic heart disease or obesity. Furthermore, an impairment of regulatory systems involves changes in physical or mental functions.

This laboratory is now working on the following main projects: unraveling the pathogenesis of atherosclerosis, the pathogenesis of kidney disease, the pathogenesis of congenital heart disease , the pathogenesis of chronic liver disease and the pathogenesis of psychiatric disorder.

The causes of kidney disease and atherosclerosis are remain to be elucidated, but there is much evidence that mitochondria dysfunctions and abnormalities of microbiome are key factors in the pathogenetic mechanisms. We aim to clarify the disorders of mitochondria and microbiome using metabolomic and epigenetic analysis for developing therapeutics by bridging basic research and clinical application.